Settings, and Pre existing characters

Paul Tevis in Episode 23 of his podcast Have Games Will Travel raises some excellent points about running something in existing settings. He talks about it in context of Pendragon and Deryni, but this is applicable to, say, Amber, or Serenity, The Black Company, or any other published setting you might use.
“Just because your players read the same book doesn’t mean that they have the same impressions of it. With any preexisting setting…its vital to identify to identify what gets you and your players excited about playing it, and figure out how to make *that* happen…”
I look forward to Tevis’ podcasts every week, both his RPG and his board game settings.